Special Article – Clinical and Experimental Allergy
This guidance for the management of patients with chronic urticaria and angio-oedema has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is aimed at both adult physicians and paediatricians practising in allergy. The recommendations are evidence graded. During the development of these guidelines, all BSACI members were included in the consultation process using a web-based system. Their comments and suggestions were carefully considered by the SOCC. Where evidence was lacking a consensus was reached by the experts on the committee. Included in this guideline are clinical classification, aetiology, diagnosis, investigations, treatment guidance with special sections on children with urticaria, and the use of antihistamines in women who are pregnant or breastfeeding. Finally, we have made recommendations for potential areas of future research.
This guidance for the management of patients with chronic urticaria/angio-oedema is intended for use by physicians treating allergic conditions. It should be recognized that patients referred to an allergy clinic often have a different pattern of presentation (e.g. intermittent acute) from those referred elsewhere and both the patient and referring practitioners often want to know whether allergy is involved. Evidence for the recommendations was collected by electronic literature searches using these primary keywords – urticaria, angio-oedema, epidemiology of management, drugs in chronic urticaria andangio-oedema, antihistamines. Each article was reviewed for suitability by the first and last authors of this guideline. The recommendations were evidence graded at the time of preparation of these guidelines. During the development of these guidelines, all British Society for Allergy and Clinical Immunology (BSACI) members were consulted using a web-based system and their comments and suggestions were carefully considered by the Standards of Care Committee (SOCC). Where evidence was lacking a consensus was reached among the expert son the committee. Conflicts of interests were recorded by the SOCC. None jeopardized unbiased guideline development.